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We treated 41 children under the age of 3 years with intracranial ependymoma between and Radiotherapy was planned for residual tumor after the completion of chemotherapy or for progression.

Results: We treated 23 boys and 18 girls who were a median 22 months old; 14 were given regimen I, 27 were given regimen II; 22 underwent complete resection, 19 had residual tumor. Ependymoma was Grade 2 in 25 patients and Grade 3 in 16; tumors were infratentorial in 37 patients and supratentorial in 4.

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One child had intracranial metastases; 29 had progressed locally after a median 9 months. One child died of sepsis, and another developed a glioblastoma 72 months after RT. Of the 13 survivors, 6 never received RT; their intellectual outcome did not differ significantly in those children than in those without RT. Conclusions: Our results confirm poor rates of event-free survival and overall survival for up-front chemotherapy in infant ependymoma.

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No better neurocognitive outcome was demonstrated in the few survivors who never received RT.

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